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KidsAP01

The project began with a feasibility study to pilot the study set up and to address the specific needs of the studies population by comparing closed loop insulin delivery using standard strength insulin and diluted insulin. The results will feed into the design of the main study.

We hypothesised that diluted insulin would lead to more stable glucose levels by reducing inaccuracies accentuated by delivery of minute amounts of insulin (frequently less that 0.1U/h [1μl/h with standard strength insulin] in small children compared to 1U/h in adults). These inaccuracies may result from pump plunger micro-jumps, tissue pressure build-up, and infusion set kinking.

Design Open-label crossover multicenter randomised control trial (n=24 children from 7 sites)
Target Population Children aged 1-7yrs with diagnosis of type 1 diabetes for at least 6 months, on insulin pump therapy for 3 or more months, willing to use continuous glucose monitoring and closed loop

 

Chief Investigator Dr Roman Hovorka, University of Cambridge
Principal Investigators Dr Carlo Acerini, Addenbrooke’s Hospital

Dr Carine de Beaufort, University of Luxembourg

Dr Fiona Campbell, St James’s University Hospital

Dr Elke Fröhlich-Reiterer, Medical University of Graz

Dr Sabine Hofer, Medical University of Innsbruck

Dr Thomas Kapellen, University of Leipzig

Dr Birgit Rami-Merhar, Medical University of Vienna

 

Recruitment
We have now reached our recruitment target of 24 young children. Thank you to the families who agreed to take part.

 

A summary of the finding from this study can be found on the here. The full article can be accessed here.

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Advanced Technologies & Treatments for Diabetes (ATTD) 2022

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KidsAP02 Study Results

We are delighted to share that the KidsAP02 study has now been published! A study summary has been shared on the …

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Fourth Annual Consortium Meeting

This year due to the COVID-19 pandemic the annual consortium meeting was hosted virtually; the meeting aimed to share each of …

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The artificial pancreas in very young children with type 1 diabetes, a H2020 European Commission funded project

Recent Posts

  • Advanced Technologies & Treatments for Diabetes (ATTD) 2022
  • KidsAP02 Study Results
  • Fourth Annual Consortium Meeting
  • Recruitment has been completed!
  • Third Annual Consortium Meeting

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    This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the grant agreement No 731560.
    The Jaeb Center for Health Research is funded by JDRF under the grant 3-SRA-2016-297-M-N.
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