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KidsAP

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KidsAP01

The project began with a feasibility study to pilot the study set up and to address the specific needs of the studies population by comparing closed loop insulin delivery using standard strength insulin and diluted insulin. The results will feed into the design of the main study.

We hypothesised that diluted insulin would lead to more stable glucose levels by reducing inaccuracies accentuated by delivery of minute amounts of insulin (frequently less that 0.1U/h [1μl/h with standard strength insulin] in small children compared to 1U/h in adults). These inaccuracies may result from pump plunger micro-jumps, tissue pressure build-up, and infusion set kinking.

Design Open-label crossover multicenter randomised control trial (n=24 children from 7 sites)
Target Population Children aged 1-7yrs with diagnosis of type 1 diabetes for at least 6 months, on insulin pump therapy for 3 or more months, willing to use continuous glucose monitoring and closed loop

 

Chief Investigator Dr Roman Hovorka, University of Cambridge
Principal Investigators Dr Carlo Acerini, Addenbrooke’s Hospital

Dr Carine de Beaufort, University of Luxembourg

Dr Fiona Campbell, St James’s University Hospital

Dr Elke Fröhlich-Reiterer, Medical University of Graz

Dr Sabine Hofer, Medical University of Innsbruck

Dr Thomas Kapellen, University of Leipzig

Dr Birgit Rami-Merhar, Medical University of Vienna

 

Recruitment
We have now reached our recruitment target of 24 young children. Thank you to the families who agreed to take part.

 

A summary of the finding from this study can be found on the here. The full article can be accessed here.

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Tweets by _RomanHovorka

Recruitment has been completed!

As of 17 June 2o2o; all sites have enrolled the target number of recruits to the KidsAP02 study. This means that all our …

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Third Annual Consortium Meeting

This year the Luxembourg team kindly hosted the KidsAP Consortium meeting which aimed to share each sites experience with the …

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Second Annual Consortium Meeting

This year the Vienna team kindly hosted the KidsAP Consortium meeting. Our main focus was the development of user interface …

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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the grant agreement No 731560.
The Jaeb Center for Health Research is funded by JDRF under the grant 3-SRA-2016-297-M-N.
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